When raising a Great Pyrenees, you need to make sure there are no narrow spaces left in the house, such as between furniture or other items, because the Great Pyrenees is very lively and active. Leaving such narrow spaces may cause the dog's head to get stuck, which can harm its health. Also, pay attention to the placement of electrical wires; they should be placed where the Great Pyrenees cannot see or reach them. When the owner goes out and leaves the dog alone at home, make sure to turn off all the power sources to avoid the puppy chewing on wires and risking electrocution and death. Additionally, any items that can be easily knocked over should not be placed where the dog can see or reach them to prevent injury from falling objects.

All medicines, insecticides, and cleaning products at home need to be carefully stored and properly closed after use to prevent the Great Pyrenees from accidental poisoning. Do not spray insecticides or other toxic gases and food in areas where the dog normally moves around. Do not casually throw away cigarette butts and ashes because they contain nicotine. If the Great Pyrenees accidentally ingests them, it may cause nicotine poisoning. Therefore, cigarette butts and ashes should be placed out of the dog's reach.

Any potentially toxic flowers planted at home should also be placed where the Great Pyrenees cannot touch them. It is best to effectively isolate any toxic plants in the yard. Items that may cause explosions or fires should be properly stored and kept out of reach, such as pressurized spray cans.

Sharp objects at home should also be properly stored and managed, as these items can easily hurt the Great Pyrenees, potentially leading to fatal consequences. Toys for the dog’s playtime should exclude hard toys made of plastic or glass balls to avoid ingestion. These are roughly the main points to pay attention to when raising a Great Pyrenees.